Genetic predisposition to MDS: diagnosis and management
نویسندگان
چکیده
منابع مشابه
Genetic predisposition syndromes and their management.
Apart from BRCA1, BRCA2, and TP53, more than a dozen breast cancer susceptibility genes have been identified. Recognizing affected individuals depends on evaluation of cancer family history and recognition of certain phenotypic markers on physical examination. Genetic testing provides a powerful tool for individualized risk stratification. Mutation carriers have several options for managing ris...
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The genetic component appears to be inherited in an autosomal dominant fashion. This means that each child has a 50% chance of inheriting. The genetic variant(s) can be inherited from either the father or the mother, and can be passed along to both sons and daughters. Current understanding of the pathogenesis of the syndrome suggests, that it is a complex multigenic disorder (a genetic problem ...
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Over recent decades a number of genes causing predisposition to cancer have been identified. Some of these cause rare autosomal dominant monogenic cancer predisposition syndromes. In the majority of families, the increased incidence of cancers is due to a multifactorial aetiology with a number of lower penetrance cancer predisposition genes interacting with environmental factors. Identification...
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Statin-associated myopathy (SAM) represents a broad spectrum of disorders from insignificant myalgia to fatal rhabdomyolysis. Its frequency ranges from 1-5 % in clinical trials to 15-20 % in everyday clinical practice. To a large extent, these variations can be explained by the definition used. Thus, we propose a scoring system to classify statin-induced myopathy according to clinical and bioch...
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ژورنال
عنوان ژورنال: Hematology
سال: 2019
ISSN: 1520-4391,1520-4383
DOI: 10.1182/hematology.2019000021